Date of Award
Doctor of Philosophy
Dr. Alan Poling
Dr. David Lyon
Dr. Jack Michael
Dr. C. Dennis Simpson
The purpose of the present study was twofold: To determine the effects of LSD (0.03 - 1.0 mg/kg), mescaline (0.3 - 5.6 mg/kg), and DMT (0.3 - 3.0 mg/kg) on the performance of pigeons under two variants on an FCN schedule and to determine whether these effects differed substantially as a result of experimental design (i.e., within subject or between-subjects). Under this schedule, food was delivered whenever subjects responded between eight and 12 times on one response key (work key), then responded once on a second key (reinforcement key). Under one version, (FCN-S^D), an external discriminative stimulus was correlated with the completion of the response requirement on the work key; no such stimulus change was programmed to occur under the other schedule (FCN).
Although small differences were apparent, within-subject and between-subjects comparisons yielded comparable results. In the absence of drug, accuracy (percent reinforced runs) was higher under the FCN-S^D schedule. LSD and DMT had little effect on accuracy under either the FCN or the FCN-S^D schedule. Mescaline, in contrast, reduced accuracy under both of these schedules.
Clark, Rodney D., "Within-Subject and Between-Subjects Evaluation of the Effects of Hallucinogenic Drugs in Pigeons Responding Under Two Variations of a Fixed-Consecutive-Number Schedule" (1990). Dissertations. 2078.