Date of Award
Doctor of Philosophy
Dr. Alan D. Poling
Resurgence is defined as the recurrence of a previously but no longer reinforced behavior when a more recently reinforced behavior undergoes extinction. The present study investigated the effects of chlordiazepoxide (CDP), a member of the class of drugs known as benzodiazepines, on the resurgence of lever pressing responses emitted by male Sprague-Dawley rats. The general procedure was as follows: An operant (left lever presses) was reinforced and subsequently extinguished. Then, a second operant (right lever presses) was reinforced. Finally, 0, 1, 3, 10, and 30 mg/kg doses of CDP were administered via intraperitoneal injections to groups of nine animals each during 3 consecutive days of 1-hr exposure to concurrent extinction schedules. Slightly more left lever pressing (the resurgence response) occurred in the 1 mg/kg group than in the control group, while dose-dependent decreases in resurgence, as well as overall responding, occurred in the 3, 10, and 30 mg/kg groups relative to control levels. These results are discussed in terms of their similarity to those found in investigations of the effects of benzodiazepines on extinction.
Weeden, Marc Alden, "The Effects of Chlordiazepoxide on Resurgence in Male Rats: A Preliminary Investigation" (2010). Dissertations. 636.