Date of Award

12-2010

Degree Name

Doctor of Philosophy

Department

Electrical and Computer Engineering

First Advisor

Dr. Ikhlas Abdel-Qader

Second Advisor

Dr. Massood Atashbar

Third Advisor

Dr. Liang Dong

Fourth Advisor

Dr. Dionysios Kountasis

Abstract

Mammographie diagnosis is the most effective technique to detect breast cancer in its infancy when it is most responsive to treatment. An early and a significant indicator of breast cancer is the presence of clustered microcalcifications (MCs). Mammographie MCs greatly vary in their appearance and shape, and become indistinguishable when surrounded by dense breast tissue. This makes radiologist's interpretation of mammograms a tedious and an error prone task.

Although computer aided diagnosis (CAD) methods are being developed to aid radiologist in detecting and analyzing the malignancy of MCs, existing systems have not achieved a satisfactory performance. The specificity of existing methods is low compared to a radiologist's interpretation. Therefore, there is a need for exploring new detection methods and developing automated, robust feature extraction and selection techniques that support the diagnosis process.

To address these needs, a detection framework that employs a pattern synthesizing process along with statistical and spectral characterization of mammograms is proposed. A trained statistical Bayesian classifier using synthetic MCs will be used to classify anonymous input patterns into a background or microcalcification classes. Morphological image processing is also proposed in this dissertation to segment and characterize the shape and the distribution of MCs. Automated nested subsets feature selection method and heuristic search method are investigated via a füll model selection using PSO-SVM framework. Furthermore, a new approach to extract texture features of MCs using a multiscale Hessian image analysis is developed and tested.

The detection and diagnosis schemes developed in this dissertation are tested using mammograms from the Mammographie Image Analysis Society (MIAS) database and compared to other existing methods. The results indicate that the performance of the detection scheme is adequate while the performance ofthe shape-based diagnosis ofMCs scheme is superior and very promising.

Comments

5th Advisor: Dr. Christina Jacobs

Access Setting

Dissertation-Open Access

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