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Proliferation of Retinal Neurons in a Mammalian Model

Faculty Mentor

Dr. Silvia Rossbach

Department

Biological Sciences

Presentation Date

4-14-2016

Document Type

Poster

Abstract

Irreversible vision loss is one of the top ten disabilities worldwide and is responsible for reduced quality of life and a substantial burden on national healthcare systems. Experiments in this study were designed to test the hypothesis that the α7 nAChR agonist, PNU-282987, leads to proliferation of adult mammalian retinal neurons. Results show proliferation of several types of retinal neurons in a time and dosage dependent manner. Furthermore, these results mirror similar regenerative paradigms in non-mammal vertebrates. These results could have serious implications for reversing vision loss due to traumatic injuries, degenerative retinal disease or age related issues.

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