Generation of rKir & rSUR2B Expression Constructs for Reconstitution of Novel K-ATP Channel ctivity in Xenopus Oocytes

Author

Kelly Biegan, Western Michigan University

Date of Defense

Fall 12-6-1999

Department

Biological Sciences

First Advisor

Steven L. Roberds, Pharmacia and Upjohn

Second Advisor

Daniel S. Everdeen, Pharmacia and Upjohn

Third Advisor

William Jackson, Biology

Abstract

The K⁺ sensitive ATP channel (K_ATP) found in various types of eukaryotic cells is an important drug target for pharmaceutical researchers. The K_ATP channel is characterized by its distinct pharmacology, inward rectification of K⁺ currents, and regulation by nucleotides. Currently, only Kir's 6.1 and 6.2 are known to form a functional K_ATP channel with a SUR. It is possible that more channels remain undiscovered, thus they are sought after as potential drug targets. Physiologists at Pharmacia and Upjohn identified a K⁺ sensitive ATP channel in rat striatal neurons which exhibits novel K_ATP channel activity and may be a potential CNS drug target for pharmaceutical researchers.

Recommended Citation

Biegan, Kelly, "Generation of rKir & rSUR2B Expression Constructs for Reconstitution of Novel K-ATP Channel ctivity in Xenopus Oocytes" (1999). Honors Theses. 134.
https://scholarworks.wmich.edu/honors_theses/134

Access Setting

Honors Thesis-Campus Only