Date of Defense
Steven L. Roberds, Pharmacia and Upjohn
Daniel S. Everdeen, Pharmacia and Upjohn
William Jackson, Biology
The K+ sensitive ATP channel (KATP) found in various types of eukaryotic cells is an important drug target for pharmaceutical researchers. The KATP channel is characterized by its distinct pharmacology, inward rectification of K+ currents, and regulation by nucleotides. Currently, only Kir's 6.1 and 6.2 are known to form a functional KATP channel with a SUR. It is possible that more channels remain undiscovered, thus they are sought after as potential drug targets. Physiologists at Pharmacia and Upjohn identified a K+ sensitive ATP channel in rat striatal neurons which exhibits novel KATP channel activity and may be a potential CNS drug target for pharmaceutical researchers.
Biegan, Kelly, "Generation of rKir & rSUR2B Expression Constructs for Reconstitution of Novel K-ATP Channel ctivity in Xenopus Oocytes" (1999). Honors Theses. 134.
Honors Thesis-Campus Only