Date of Defense
David Huffman, Chemistry
Sherine Obare, Chemistry
Bruce Bejcek, Biological Sciences
A key aspect of globular protein biogenesis is folding. While protein folding is an incompletely understood process, the facts that this is closely monitored by the cell and that this monitoring, under native conditions, helps ensure homeostatic maintenance of the proteome, proteostasis, are becoming increasingly clear. When proteostasis goes awry disease can ensue. A number of diseases are associated with protein misfolding due to various causes Two broad classes of consequences can result. Toxic gain-of-function occurs most often with the formation of aggregates of misfolded proteins which may kill cells or incite the inflammatory response. Examples include Alzheimer's disease and Parkinson's disease.
Blok, Neil, "Post-Translational Modifications and Thapsigargin-Induced Localization Effects on Human Endoplasmic Reticulum Mannosidase I" (2010). Honors Theses. 136.
Honors Thesis-Campus Only