A representative sample of the U.S. workforce from 1997 National Study of the Changing Workforce data (Families & Work Institute, 1999) was examined to study the relationship between shift work and negative workto- family spillover. Negative spillover was measured by Likert-scale frequency responses to questions concerning mood, energy, and time for family as functions of one's job. Statistical analyses comprised t-tests, ANOVAs, and multiple regressions. Among wage earners with families (n = 2,429), shift work showed a significant, strong, positive relationship to high negative work-to-family spillover when controlling for standard demographic characteristics as well as education and occupation. Distinctions among evening, night, rotating and split shifts revealed the highest negative spillover for rotating shift workers. Additional workrelated factors influencing negative spillover included number of work hours, preference for fewer work hours (positive associations), supervisory support, job autonomy, and a family-supportive job culture (negative associations).