Date of Award
4-1986
Degree Name
Master of Science
Department
Biological Sciences
First Advisor
Dr. Leonard C. Ginsberg
Second Advisor
Dr. Darwin Buthala
Third Advisor
Dr. Leonard Beuving
Access Setting
Masters Thesis-Open Access
Abstract
Yeast mannans are phosphorylated glycopeptides found in various species of yeast. Their similarity to the mannose-phosphate signal for intracellular lysosomal uptake led mannans to be considered as a possible vehicle for increasing cellular affinity for peptides. Insulin was used as a model peptide and was conjugated to mannans by two coupling methods. The conjugated mannan-insulins were compared to insulin on the basis of cellular binding and ability to induce typical insulin biological effects.
Recommended Citation
Lee, Jacqueline Cesario, "Yeast Mannans: Use as a Transport Vehicle for Peptides" (1986). Masters Theses. 1332.
https://scholarworks.wmich.edu/masters_theses/1332