Date of Award

12-1981

Degree Name

Master of Science

Department

Biological Sciences

First Advisor

Dr. Cecil Mclntire

Second Advisor

Dr. Leonard Ginsberg

Third Advisor

Dr. Gyula Ficsor

Access Setting

Masters Thesis-Open Access

Abstract

With each passing year, humans are exposed to ever increasing numbers of chemical agents, many of which may have mutagenic, carcinogenic, or teratogenic effects on the human species. Animal studies must be performed on any chemical substance that is suspected of being acutely dangerous to humans by way of cancer induction or inducted malformations to infants. Seven drugs of known or suspected mutagenic, carcinogenic, or teratogenic potential were examined for their ability to induce histopathology in the testes and epididymides of CF-1 mice. Mitomycin-C, hydroxyurea, and adriamycin induced significant histopathology whereas predisolone, thalidomide, streptomycin sulfate, and polybrominated biphenyl induced minimal or no histopathology to the testes and epididymides. The results of this project will provide additional information on the toxicity and teratogenic potentials of these chemical agents.

Included in

Anatomy Commons

Share

COinS