Date of Award

1980

Degree Name

Master of Science

Department

Biological Sciences

First Advisor

Dr. Darwin Buthala

Second Advisor

Dr. William Dulin

Access Setting

Masters Thesis-Open Access

Abstract

This research was done to determine whether any ABH-like blood group system was present in Chinese hamsters (Cricetulus griseus). The population of animals included 35 hamsters, 20 "normal" or outbred (10 males; 10 females) and 15 diabetic from The Upjohn Company's colony of inbred diabetic animals (8 males; 7 females; BE and BA lines). Animal sera and erythrocytes were compared by: hyperimmunization of rabbits (10 New Zealand White) with hamster erythrocytes; screening hamster erythrocytes and plasmas with human blood diagnostic typing antisera (Ortho Diagnostics), anti-H lectin, anti-A1 lectin and human red cells of various types; absorption and elution of rabhit anti-hamster erythrocyte sera; gel diffusion of Ouchterlony; and electron microscopy. Results show that there are antigens present on hamster red blood cells which are specific for or at least cross-reactive with human A and B antigenic specificities, very possibly of the A2 or A2 B subgroup. We conclude that Chinese hamsters show ABH-like specificities.

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