Date of Award


Degree Name

Doctor of Philosophy



First Advisor

Dr. Alan D. Poling

Second Advisor

Dr. Frederick Gault

Third Advisor

Dr. David Lyon

Fourth Advisor

Dr. Clarence Goodnight


The effects of tripelennamine (3, 6, 12, 18, and 24 mg/kg) and pentazocine (5, 10, 20, 30, and 40 mg/kg), given alone and in selected combinations, were determined in rats performing under fixed-ratio 30 and interresponse-time-greater-than-15-second schedules of food delivery. When given alone, tripelennamine and pentazocine produced statistically significant decreases in responding under the fixed-ratio 30 schedule, but did not significantly affect responding under the interresponse-time-greater-than-15-second schedule. Each drug alone significantly decreased the number of reinforcers (food pellets) earned relative to control values under both schedules. The effects of the two drugs in combination were supra-additive. That is, the effects of a given dose of tripelennamine and pentazocine together were identical in direction to, and significantly greater, than the arithmetic summation of the effects of the drugs given alone.

Access Setting

Dissertation-Open Access