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Proliferation of Retinal Neurons in a Mammalian Model

Faculty Mentor

Dr. Silvia Rossbach


Biological Sciences

Presentation Date


Document Type



Irreversible vision loss is one of the top ten disabilities worldwide and is responsible for reduced quality of life and a substantial burden on national healthcare systems. Experiments in this study were designed to test the hypothesis that the α7 nAChR agonist, PNU-282987, leads to proliferation of adult mammalian retinal neurons. Results show proliferation of several types of retinal neurons in a time and dosage dependent manner. Furthermore, these results mirror similar regenerative paradigms in non-mammal vertebrates. These results could have serious implications for reversing vision loss due to traumatic injuries, degenerative retinal disease or age related issues.

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