Date of Defense

Fall 12-6-1999


Biological Sciences

First Advisor

Steven L. Roberds, Pharmacia and Upjohn

Second Advisor

Daniel S. Everdeen, Pharmacia and Upjohn

Third Advisor

William Jackson, Biology


The K+ sensitive ATP channel (KATP) found in various types of eukaryotic cells is an important drug target for pharmaceutical researchers. The KATP channel is characterized by its distinct pharmacology, inward rectification of K+ currents, and regulation by nucleotides. Currently, only Kir's 6.1 and 6.2 are known to form a functional KATP channel with a SUR. It is possible that more channels remain undiscovered, thus they are sought after as potential drug targets. Physiologists at Pharmacia and Upjohn identified a K+ sensitive ATP channel in rat striatal neurons which exhibits novel KATP channel activity and may be a potential CNS drug target for pharmaceutical researchers.

Access Setting

Honors Thesis-Campus Only