The Use of Indomethacin to Prevent Heterotopic Ossificiation Following Operative Treatment of Acetabular Fractures
Date of Defense
Leonard J. Beuving, Biological Sciences
Christine A. Byrd, Biological Sciences
Jan Hall, University of Michigan
The effect of indomethacin on heterotopic ossification following surgical treatment of acetabular fractures was analyzed with respect to occurrence and severity of heterotopic ossification. The study was randomized, placebo-controlled, and double-blind. The Brooker/Moed Classification system was used to determine the level of heterotopic ossification that was present in each patient at the six-week follow-up visit. The analyses were performed on pilot data. Seven out of the eighteen subjects showed radiographic evidence of hetertopic ossification. Of these seven, three were in the placebo group and four were in the indomethacin group. A Pearson chi sqaure test was used to compare the difference in the rate of heterotopic ossification among the experiment groups. The difference was not found to be statistically significant. Due to the small sample size, the results obtained do not necessarily reflect the actual effects of indomethacin on the formation of heterotopic bone. A sample size of 118 subjects is necessary to achieve statistical power of 80%. When completed, the full study is expected to show whether or not indomethacin is effective in reducing the severity of heterotopic ossification under the above-mentioned circumstances.
Bodnar, Vanessa R., "The Use of Indomethacin to Prevent Heterotopic Ossificiation Following Operative Treatment of Acetabular Fractures" (2001). Honors Theses. 137.
Honors Thesis-Campus Only