Date of Defense

Spring 4-19-2006


Biological Sciences

First Advisor

Cindy Linn, Biological Sciences

Second Advisor

John Spitsbergen, Biological Sciences

Third Advisor

Daniel Kueh, Biological Sciences


In this study, experiments were performed to precondition cells with calcium to support the hypothesis that a preconditioning dose of calcium into cells will lead to neuroprotection against glutamate-induced excitotoxicity in pig RGCs. Cells will be introduced to relatively low levels of calcium using different procedures. This will help determine whether preconditioning calcium pulses provide neuroprotection against a harsher insult. Results from this study will support or refute the hypothesis that preconditioning cells with low concentrations of calcium triggers neuroprotection and will help shape future studies focusing on the nAChRs and their role in neuroprotection. In the future, many therapeutic agents may be developed to combat various diseases with glutamate-induced excitotoxicity, including glaucoma.

Access Setting

Honors Thesis-Campus Only