Date of Defense

Spring 4-1-1980


Biological Sciences

First Advisor

J. Patrick McGovren

Second Advisor

Leonard Beuving


Disposition studies of the antitumor agent AT-125 in rats were undertaken to determine the relative importance of urinary and fecal excretion and metabolism as routes of elimination of the drug, to examine the kinetics of plasma level decline, and to determine whether there were any significant sex-related differences in any of these areas. Studies resulted in a wide range of total percent of the original dose recovered. Nearly all recovered drug was found in the urine, indicating that the urine was the principal route of excretion with elimination via the biliary system being not significant. Incomplete record of the drug in urine indicated that metabolism to other compounds was also a significant route of elimination. No significant sex-related differences were noted.


Includes comments and corrections.

Access Setting

Honors Thesis-Campus Only