Date of Defense

Spring 3-4-1996

Date of Graduation



Biological Sciences

First Advisor

Gail Zipp, Upjohn


The alarming spread of AIDS has inspired a world-wide effort to disable the causative agent of AIDS, the human immunodeficiency virus (HIV). Pharmacia and Upjohn, Inc. has taken the first approach to AIDS research: AIDS is likely to be controlled by a combination of treatments that target the virus at various stages in its life cycle. The development of protease inhibitors and non-nucleoside reverse transcriptase inhibitors are two examples of target directed therapies. In this review, the author describes the overall process of pharmaceutical development of the HIV-Protease Inhibitor.

Access Setting

Honors Thesis-Campus Only