Date of Defense
The capability of maternal and 18 day fetal liver and placental homogenates from CF-1 mice to catabolize corticosterone was measured. Tissues from pregnant animals treated with corticosterone 24 and 48 hours prior to sacrifice demonstrated no difference in the rate of hepatic catabolism of corticosterone in either maternal or fetal liver tissue samples, compared to the control (sesame oil-treated) group. A relative decreased capacity for hepatic corticosterone catabolism was observed in homogenates of both maternal and fetal liver from mice treated with ACTH 24 and 48 hours prior to sacrifice. Corticosterone catabolism in the placenta of corticosterone-treated mice increased, while placental catabolism in ACTH-treated animals decreased, relative to the control group.
Mulder, John A., "Stress-Related Enzymatic Catabolism of Corticosterone in Maternal and Fetal Mouse Tissues" (1974). Honors Theses. 227.
Honors Thesis-Campus Only