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The goal of this study was to synthesize three novel B-ring modified 1,10-phenanthroline derivatives. The growing need for new antibiotics due to the significant number of microbial species that are becoming resistant to broad spectrum antimicrobial agents have given the impetus to explore novel compounds with antimicrobial activity. Three new 1,10-phenanthrolines were synthesized. Three amines served as nucleophiles to open an epoxide intermediate to afford the target compounds. A disk diffusion assay was used to determine the antimicrobial activity of the synthesized compounds.
Moses, Marcus, "1.10 - Phenanthroline Derivatives as Potential Antimicrobial Agents" (2012). Honors Theses. 2354.