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Date of Graduation
In light of recent findings in regards to the worsening state of the environment, the necessity for green methodologies is becoming more and more apparent. One area of green chemistry that has been underexplored is the combination of a catalyst and green solvent system. Of particular interest are the N-Heterocyclic Carbenes (NHC's) a versatile class of organocatalysts capable of a variety of carbon-carbon bond forming reactions. However, little research has been done exploring the use of NHCs in unconventional solvent systems. The solvents of choice for the typical model reaction the benzoin condensation include dichloromethane, tetrahydrofuran, and methanol. The investigation of the benzoin condensation in newer green solvents has received much less attention. In our presentation we will described our work on the reaction and stereoselectivity of the NHC catalyzed benzoin condensation in newer green solvents.
Thayer, William, "Asymmetric Reaction of N-Heterocyclic Carbenes in Green Solvents" (2014). Honors Theses. 2453.