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The oxazole functional group has a wide variety of uses in material science and pharmacology. Synthesis can take place through a variety of methods and involve several major organic functional groups. However, research on cyclization of the five-membered ring directly from amino alcohols has received little attention. In this research study, 2-(2,4,6- trimethoxyphenyl) oxazolo [4,5-f][1,10] phenanthroline (3b) and 2-(3-methoxyphenyl) oxazolo [4,5- f][1,10] phenanthroline (3a) were synthesized from 1,10-phenanthroline-5,6-epoxide (1) with good yield.
Alkema, Evan, "1,10-Phenanthroline amino alcohol derivatives as oxazole precursors" (2014). Honors Theses. 2493.