Date of Defense
12-8-2020
Date of Graduation
12-2020
Department
Interdisciplinary Health Programs
First Advisor
Wendy Beane
Second Advisor
David Huffman
Third Advisor
Alanna Van Huizen
Abstract
Reactive oxygen species (ROS) have been found to be a conserved signaling component in the wound closure process in many species, ranging from humans to the planarian flatworm Schmidtea mediterranea. Previous data has shown that ROS acts as a second messenger in the in stress/inflammatory responses and the subsequent tissue/neuron repair process following injury. I hypothesize that ROS will be required for wound closure in planarians. Experiments consisted of analyzing untreated planarian wound closure and quantifying ROS accumulation levels between 15 to 60 minutes after amputation. A time course of normal wound closure was established up to one hour after amputation. The use of pharmacological modulation of ROS accumulation was used as a tool to investigate the importance of ROS in wound closure. These data show that ROS is required for wound closure to occur normally in planarians.
Recommended Citation
Greene, Jacqueline, "The Role of Reactive Oxygen Species in Planarian Wound Closure" (2020). Honors Theses. 3338.
https://scholarworks.wmich.edu/honors_theses/3338
Access Setting
Honors Thesis-Restricted
Restricted to Campus until
2-4-2023