Date of Defense

12-8-2020

Date of Graduation

12-2020

Department

Interdisciplinary Health Programs

First Advisor

Wendy Beane

Second Advisor

David Huffman

Third Advisor

Alanna Van Huizen

Abstract

Reactive oxygen species (ROS) have been found to be a conserved signaling component in the wound closure process in many species, ranging from humans to the planarian flatworm Schmidtea mediterranea. Previous data has shown that ROS acts as a second messenger in the in stress/inflammatory responses and the subsequent tissue/neuron repair process following injury. I hypothesize that ROS will be required for wound closure in planarians. Experiments consisted of analyzing untreated planarian wound closure and quantifying ROS accumulation levels between 15 to 60 minutes after amputation. A time course of normal wound closure was established up to one hour after amputation. The use of pharmacological modulation of ROS accumulation was used as a tool to investigate the importance of ROS in wound closure. These data show that ROS is required for wound closure to occur normally in planarians.

Access Setting

Honors Thesis-Restricted

Restricted to Campus until

2-4-2023

Available for download on Saturday, February 04, 2023

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