Date of Defense
According to the Hughes-Ingold theory of solvent effects on reaction kinetics, a more polar solvent will decrease or increase the heat of activation (to which the Arrhenius energy of activation is the usual approximation) depending on whether the transition state of the reaction is more or less polar than the initial state of the reactants. Counter acting changes may occur in the entropy of activation (approximately represented by the Arrhenius frequency factor); but the qualitative theory assumes that the energy change will dominate the rate change. Therefore a more polar solvent will accelerate or retard reaction according to whether the transition state is more or less polar than the initial state.
Adams, Wade J., "Solvent and Substituent Effects on the Lossen Rearrangement of Benzoyl Arylhydroxamates" (1965). Honors Theses. 630.
Honors Thesis-Campus Only