Date of Defense
Sherine Obare, Chemistry
Steven Bertman, Chemistry
The creation of new materials for sensing requires careful manipulation of the responsive units required to control analyte selectivity. We have developed a series of molecular sensors based on dipyrido-[3,2-a:2'3,-c]phenazine (DPPZ). Rational choice of substituents at the 3 and 6 positions and the back-end phenazine unit of DPPZ allow manipulation of optical and electrochemical properties required to selectively distinguish between various toxic organophosphorus-based pesticides. We have demonstrated that 3,6-dialkylbenzo[i]dipyrido-[3,2-a:2'3'-c]phenazine in comparison to benzo[i]dipyrido- [3,2-a:2'3'-c]phenazine shows significant differences in the optical output upon interaction with the organophosphorus pesticides fenthion, paraoxon, malathion and ethion. The compounds show promise as electrochemical sensors as well. This is advantageous because the ability of a sensor to provide two independent signals upon analyte detection minimizes the possibility of false positives.
Engelmann, Brigitte J., "Fluorescence-Based Organophosphorus Pesticide Detection" (2007). Honors Theses. 710.
Honors Thesis-Campus Only