Date of Award


Degree Name

Master of Arts



First Advisor

Dr. Malcolm H. Robertson

Second Advisor

Dr. R. Wayne Fuqua

Third Advisor

Dr. Gyula Ficsor

Access Setting

Masters Thesis-Open Access


Groups of 10, 8 and 6 HA(1CR) adult male mice were injected by a single intraperitoneal injection with 100 mg Ethyl-Nitrosourea, 2.5 mg Mitomcyin C or a saline Control. Treatment was administered in milligram per kilogram of body weight. Each male was mated to two untreated females during the fifth week after treatment. Progeny were evaluated by observations of reproduction, development, motor reflex, motor coordination and locomotor activity. Decreased weights were seen during the preweaning period among offspring from Mitomycin C treated males. The Mitomycin C group demonstrated consistent deficits in water escape performance. Mitomycin C progeny also exhibited one deficit in direction of movement during the swim test, later showing a recovery. The Ethyl-Nitrosourea group exhibited a consistent increase in motor activity during the open-field test. The developmental and behavioral impairments shown above may indicate a low level geno-toxic effect.

Included in

Psychology Commons