Date of Award
Master of Arts
Dr. Robert E. Harmon
Masters Thesis-Open Access
The synthesis of 5-arylazopyrimidines was undertaken in search of potential anticancer agents.
While many azo compounds have carcinogenic activity, it has been shown by several workers in this area that some 5-arylazopyrimidines have anticancer properties. S. Hibino(1) has shown that p-(2,4,6-triamino-5-pyrimidinylazo) benzene-sulfonic acid shows promise as an effective anticancer agent when used in conjunction with 6-mercaptopurine and adrenal steroidal hormones. When tested clinically, total remission of the leukemic process was achieved in 85.7% of the cases treated. In comparison, total remission was achieved in only 57.5% of the cases treated with a mixture of 6-MP and the hormone which did not include the azopyrimidine.
This paper discusses the synthesis of nine 5-arylazo-pyrimidines and includes the preliminary results of bio- logical testing performed by Cancer Chemotherapy National Service Center.
Dutton, Frederic Edwin, "The Preparation of 5-Arylazopyrimidines" (1965). Masters Theses. 4381.