Date of Award

12-1965

Degree Name

Master of Arts

Department

Chemistry

First Advisor

Dr. Robert Harmon

Access Setting

Masters Thesis-Open Access

Abstract

Introduction

The synthesis of 5-arylazopyrimidines was undertaken in search of potential anticancer agents.

While many azo compounds have carcinogenic activity, it has been shown by several workers in this area that some 5-arylazopyrimidines have anticancer properties. S. Hibino(1) has shown that p-(2,4,6-triamino-5-pyrimidinylazo) benzene-sulfonic acid shows promise as an effective anticancer agent when used in conjunction with 6-mercaptopurine and adrenal steroidal hormones. When tested clinically, total remission of the leukemic process was achieved in 85.7% of the cases treated. In comparison, total remission was achieved in only 57.5% of the cases treated with a mixture of 6-MP and the hormone which did not include the azopyrimidine.

This paper discusses the synthesis of nine 5-arylazo-pyrimidines and includes the preliminary results of bio- logical testing performed by Cancer Chemotherapy National Service Center.

Included in

Chemistry Commons

Share

COinS