Date of Award
Master of Arts
Dr. Robert E. Harmon
Dr. Robert C. Nagler
Dr. Don C. Iffland
Masters Thesis-Open Access
The purpose of this research is to prepare the CIS and TRANS isomers of the 2, 3 and 4-methylcyclohecanecarboxylic acids and their 2-diethylaminoethyl esters.
This series of compounds is of interest because of the anti-tumor activity shown by some ethanolamine derivatives. The compounds to be prepared in this study represent modifications of these structures to determine if further investigation in this area is worthwhile. A pharmacological evaluation of these compounds will be made since many esters of amino alcohols have demonstrated pharmacological activity. The cancer chemotherapeutic and pharmacological test results are not included in this paper, but will be published elsewhere.
Meulman, "Preparation of the CIS and TRANS Isomers of Methylcyclohexanecarboxylic Acids and Their 2-Diethylaminoethyl Esters" (1963). Master's Theses. 4394.