Date of Award

12-1981

Degree Name

Doctor of Philosophy

Department

Psychology

First Advisor

Dr. David Lyon

Second Advisor

Dr. Arthur Snapper

Third Advisor

Dr. Alan Poling

Fourth Advisor

Dr. C. Dennis Simpson

Abstract

The present studies examined the effects of acute and chronic administrations of phenytoin on the responding of pigeons and rats maintained under fixed-ratio, fixed-interval, and interresponse-time-greater-than-t schedules of food reinforcement. These schedules typically engender different rates and temporal patterns of responding and are often differentially affected by drugs. The results indicated that phenytoin, given acutely, produced dose-dependent decreases in the response rate of rats and pigeons maintained under fixed-ratio and fixed-interval schedules. Response rates under the fixed-interval and inter response-time-greater-than-t schedules were little affected by the drug. A degree of tolerance was observed to phenytoin's rate-decreasing effects when the drug was given chronically. These findings are contrasted with the behavioral actions of other anticonvulsants, and their possible clinical implications discussed.

Access Setting

Dissertation-Open Access

Included in

Psychology Commons

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