Date of Award

6-2009

Degree Name

Master of Science in Engineering

Department

Electrical and Computer Engineering

Access Setting

Masters Thesis-Campus Only

Abstract

A Micro-Electrode Array or Multi-Electrode Array (MEA) is a commercially available device that provides an array of electrodes plated on the bottom of a cell culture dish. The electrodes may be used to stimulate and/or measure electrical activity in a neuron cell culture. As described in the article "An Integrated System for Simultaneous, Multichannel Neuronal Stimulation and Recording" by Blum et al. in IEEE Transactions on Circuits and Systems, electrode voltage amplitudes are typically no larger than lOOuV with millivolt offset voltages in a bandwidth of approximately lOHz to 3kHz. This document describes a dual channel amplifier prototype with a stimulation capability that has been designed based as previous work at WMU as inspired by existing systems. Functionality of the amplifier and stimulation system was experimentally validated by implementing a standard neurophysiology experiment based on earthworm giant axon action potentials. Validation of this prototype will provide a basis for a planned sixty channel system to duplicate the functionality of existing systems.

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