Date of Award


Degree Name

Doctor of Philosophy



First Advisor

Dr. Frederick Gault

Second Advisor

Dr. Alan Poling


The effects of pentazocine and tripelennamine, alone and in combination, were assessed on measures of analgesia (hot plate test) and locomotion (open field) in rats and mice. In Experiment 1, the combination of pentazocine and tripelennamine was found to produce analgesia at doses which were not analgesic when the drugs were given alone. This combination also reestablished analgesia in subjects made tolerant to pentazocine's effects. In Experiment 2, development of tolerance to the analgesic effects of pentazocine was delayed by addition of tripelennamine. In Experiment 3, locomotion was decreased by pentazocine at the highest dose. A similar reduction was produced by combining tripelennamine with lower doses of pentazocine. The relation of these data to the rising popularity of pentazocine and tripelennamine abuse is discussed.

Access Setting

Dissertation-Open Access