Date of Award


Degree Name

Doctor of Philosophy



First Advisor

Dr. Lisa E. Baker


Alzheimer’s disease is a progressive neurodegenerative disease characterized by memory loss and cognitive decline. Although the symptomology of Alzheimer’s disease is well defined, its precise etiology remains elusive. Animal models are invaluable for understanding the pathogenesis of this devastating disease. Knowledge of the neurochemical actions of amyloid-β oligomers in specific brain structures is essential for validating animal models of Alzheimer’s disease and for determining the most appropriate behavioral assays of memory. The specific aim of this project was to investigate the neurochemical effects of direct intracerebral infusion of amyloid-β oligomers in the rat. Experiment 1 investigated direct infusions of synthetic amyloid-β oligomers and experiment 2 examined cell-derived amyloid-β oligomer infusion in the rat prefrontal cortex. Neurochemical efflux was measured in the PFC using in vivo microdialysis and monoamine metabolite concentrations were determined using HPLCEC. Results showed a reduction in 5-HIAA one hour post infusion of cell derived oligomers. This reduction is indicative of the involvement of the serotonergic system in Alzheimer’s disease.

Access Setting

Dissertation-Open Access