Date of Defense
Spring 4-1974
Department
Biological Sciences
First Advisor
Leonard Beuving
Abstract
The capability of maternal and 18 day fetal liver and placental homogenates from CF-1 mice to catabolize corticosterone was measured. Tissues from pregnant animals treated with corticosterone 24 and 48 hours prior to sacrifice demonstrated no difference in the rate of hepatic catabolism of corticosterone in either maternal or fetal liver tissue samples, compared to the control (sesame oil-treated) group. A relative decreased capacity for hepatic corticosterone catabolism was observed in homogenates of both maternal and fetal liver from mice treated with ACTH 24 and 48 hours prior to sacrifice. Corticosterone catabolism in the placenta of corticosterone-treated mice increased, while placental catabolism in ACTH-treated animals decreased, relative to the control group.
Recommended Citation
Mulder, John A., "Stress-Related Enzymatic Catabolism of Corticosterone in Maternal and Fetal Mouse Tissues" (1974). Honors Theses. 227.
https://scholarworks.wmich.edu/honors_theses/227
Access Setting
Honors Thesis-Campus Only