Date of Defense

Spring 3-18-2002


Biological Sciences

First Advisor

William Jackson, Biological Sciences

Second Advisor

John Spitsbergen, Biological Sciences

Third Advisor

Terry Baumann, Munson Medical Center


Coumadin, Jantoven, Marevan, Lawarin, Waran, Warfant


Warfarin, an oral anticoagulant, is often used prophylactically to treat patients who will be undergoing major orthopedic surgery. Warfarin works as a vitamin K antagonist to prevent blood clots from forming as a result of immobility after surgery. THe degree of anticoagulation in the blood is measured using an international standardized ratio (INR) of the prothrombin time. This study was performed to determine the efficacy of Munson Medical Center's Pharmacy Anticoagulation Clinic Team (PACT) in successfully treating orthopedic surgery patients. Target INR values were between 2 and 3. The values and statistics calculated show that the program has been effective, with the mean INR value after discharge falling into the target range. This information can be helpful for clinicians who are investigating warfarin dosing protocols and the potential side effects of using oral anticoagulants.

Access Setting

Honors Thesis-Campus Only