Date of Award
Master of Arts
Dr. Alan D. Poling
Dr. Henry Schlinger
Dr. Marilyn K. Malott
Masters Thesis-Open Access
Previous research has shown that ethosuximide in high enough doses will disrupt operant responding in pigeons. Whether or not these same doses will protect against seizure activity in this species has not been previously tested.
To test this question a system for scoring pentylenetetrazol-induced seizures in pigeons was developed and the effects of ethosuximide on such seizures were evaluated. In Experiment 1 pentylenetetrazol at 15, 27 and 47 mg/kg reliably induced seizures. In Experiment 2 non-behaviorally active and behaviorally active doses of ethosuximide were tested for their seizure controlling effectiveness.
Doses of 20, 40, 80, 160 and 320 mg/kg ethosuximide had little effect on seizures; 640 mg/kg significantly reduced but did not completely eliminate seizures.
Jakubow, James J., "Pentylenetetrazol-Induced Seizures in Pigeons and the Effects of Ethosuximide Thereon" (1988). Masters Theses. 1199.