Date of Award


Degree Name

Master of Science


Biological Sciences

Access Setting

Masters Thesis-Open Access


Research has produced evidence associating progressive, bilateral, sensorineural hearing loss with diabetes mellitus in human and animal subjects. The microangiopathy which is presumably the cause of hearing loss appears similar to the microangiopathy leading to retinal and renal atrophy.

In the present study the temporal bones of six streptozotocininduced diabetic Chinese hamsters and six nondiabetic Chinese hamsters were histologically processed. Sections stained with hematoxylin and eosin were assessed for total auditory and vestibular otopathology and revealed no statistically significant differences between the two groups. Sections stained with periodic acid-Schiff's were evaluated for vascular basement membrane changes and revealed no statistically significant differences between groups Streptozotocin-induced diabetes in the Chinese hamster may not be an adequate model for study of diabetes-induced otopathologies.