Date of Award
12-1981
Degree Name
Master of Science
Department
Biological Sciences
First Advisor
Dr. Cecil L. MeIntire
Second Advisor
Dr. Leonard Ginsberg
Third Advisor
Dr. Gyula Ficsor
Access Setting
Masters Thesis-Open Access
Abstract
With each passing year, humans are exposed to ever increasing numbers of chemical agents, many of which may have mutagenic, carcinogenic, or teratogenic effects on the human species. Animal studies must be performed on any chemical substance that is suspected of being acutely dangerous to humans by way of cancer induction or inducted malformations to infants. Seven drugs of known or suspected mutagenic, carcinogenic, or teratogenic potential were examined for their ability to induce histopathology in the testes and epididymides of CF-1 mice. Mitomycin-C, hydroxyurea, and adriamycin induced significant histopathology whereas predisolone, thalidomide, streptomycin sulfate, and polybrominated biphenyl induced minimal or no histopathology to the testes and epididymides. The results of this project will provide additional information on the toxicity and teratogenic potentials of these chemical agents.
Recommended Citation
Block, Kevin K., "The Induced Histopathology of the Testes and Epididymides of Cf-1 Mice by Known or Suspected Teratogens, Mutagens, and Carcinogens" (1981). Masters Theses. 1840.
https://scholarworks.wmich.edu/masters_theses/1840