Time-Related Changes in Rat Androgen Binding Protein Following a Sterilizing Dose of 3-Chloro-1, 2-Propanediol
Date of Award
Master of Science
Dr. Leonard J. Beuving
Dr. Thomas J. Lobl
Dr. Jack Wood
Masters Thesis-Open Access
Androgen binding protein (ABP) is produced by the Sertoli cell, regulated by FSH and androgens, secreted into the testicular fluid, and transported into the caput epididymis where it is thought to play a role in sperm maturation. In this study, the response of ABP to a lesion created chemically by administration of a single, oral 60 mg/kg dose of alpha-chlorohydrin was examined in ninety day old male rats. Total testicular ABP content increased progressively for four days after treatment and there after declined whereas, epididymal ABP concentration decreased immediately. Serum testosterone showed no significant variation from controls, however, serum FSH and LH levels did change from controls. Serum FSH levels remained generally unchanged until day ten and was increased on day twenty, whereas LH increased slowly, reaching maximal concentration on day ten. The overall effect of the above stated changes suggests that ABP production continues following treatment with alpha-chlorohydrin.
Stein, Shirley J., "Time-Related Changes in Rat Androgen Binding Protein Following a Sterilizing Dose of 3-Chloro-1, 2-Propanediol" (1979). Masters Theses. 2048.