Date of Award
Master of Science in Engineering
Electrical and Computer Engineering
Dr. Frank L. Severance
Dr. Damon A. Miller
Dr. Bradley J. Bazuin
Dr. John W. Gesink
Masters Thesis-Campus Only
The Neurobiology Engineering Laboratory at Western Michigan University is investigating stimulus/response relationships of physiological neural networks via acquisition and analysis of the associated electrical signals. A number of issues including the physical size of neurons of interest, accessibility to neurons within compact physical structures, and small signal amplitudes make data acquisition a complex endeavor. The stochastic nature of action potential generation in physiological neural networks complicates data analysis. To this end, planned research in the Neurobiology Engineering Laboratory will involve specialized glass Petri dishes with micrometer scale embedded electrodes known as microelectrode arrays. Cultures of neurons may be grown directly on top of this electrode array to enable extracellular stimulation and measurement of neural network activity. This thesis describes foundational work for the Neurobiology Engineering Laboratory, including configuration of the laboratory, validation of cell culture protocols, and developed data analysis software based on existing neuron modeling techniques. Those techniques are applied to experimental data.
Ellinger, Michael E., "Acquisition and Analysis of Biological Neural Network Action Potential Sequences" (2009). Masters Theses. 232.