Date of Award
6-2009
Degree Name
Master of Science in Engineering
Department
Electrical and Computer Engineering
Access Setting
Masters Thesis-Campus Only
Abstract
A Micro-Electrode Array or Multi-Electrode Array (MEA) is a commercially available device that provides an array of electrodes plated on the bottom of a cell culture dish. The electrodes may be used to stimulate and/or measure electrical activity in a neuron cell culture. As described in the article "An Integrated System for Simultaneous, Multichannel Neuronal Stimulation and Recording" by Blum et al. in IEEE Transactions on Circuits and Systems, electrode voltage amplitudes are typically no larger than lOOuV with millivolt offset voltages in a bandwidth of approximately lOHz to 3kHz. This document describes a dual channel amplifier prototype with a stimulation capability that has been designed based as previous work at WMU as inspired by existing systems. Functionality of the amplifier and stimulation system was experimentally validated by implementing a standard neurophysiology experiment based on earthworm giant axon action potentials. Validation of this prototype will provide a basis for a planned sixty channel system to duplicate the functionality of existing systems.
Recommended Citation
Stahl, John D., "Dual Channel Low Noise Amplifier for Experiments In Neurophysiology" (2009). Masters Theses. 239.
https://scholarworks.wmich.edu/masters_theses/239