Date of Award

4-1971

Degree Name

Master of Arts

First Advisor

Dr. D. O. Lyon

Second Advisor

Dr. N. D. Kent

Third Advisor

Dr. F. Gault

Access Setting

Masters Thesis-Open Access

Abstract

The present study was designed to investigate the effectiveness of a two lever escape avoidance paradigm as a potential drug evaluation procedure. In this procedure responses on one lever postponed the onset of shock for a fixed period of time while responses on the other lever were effective only in terminating shock. This procedure effectively separates the escape and avoidance behaviors of a single organism and should provide a sensitive baseline upon which to measure the specific effects of drugs upon these two behaviors. The specific and differential effects of three dose levels of chlorpromazine upon escape and avoidance behaviors were evaluated on this baseline.

The results showed that while the rate of avoidance behavior was found to be decreased by the administration of chlorpromazine, other inappropriate responses increased. These data were interpreted as indicating that chlorpromazine may not selectively block avoidance behavior but simply increase interfering behaviors.

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