Date of Award
Master of Arts
Dr. Robert E. Harmon
Masters Thesis-Open Access
The purpose of this research was to prepare the bisarylsulfonic acid esters of 1,4-butanediol and 1,4-but-2-ynediol.
This series of compounds is of interest because of the antitumor activity exhibited by the bismethanesulfonates of 1,4-butanediol and 1,4-but-2-ynediol. The compounds which were prepared were submitted to Cancer Chemotherapy National Service Center for evaluation in their anticancer program.
It was hoped that the compounds synthesized would be of pharmacological value. It was further hoped that the biological test data of these compounds would demonstrate a correlation between types of substituents on the aromatic nucleus and the degree of activity of the compounds. It was also hoped that biological test results would shed some light on the mechanism of action of the bissulfonic acid esters.
Earl, Robert A., "Carcinostatic Sulfonic Acid Esters of Selected 1,4-Diols" (1965). Masters Theses. 4388.