Date of Award


Degree Name

Master of Arts



First Advisor

Dr. Frederick P. Gault

Second Advisor

Dr. Alan Poling

Access Setting

Masters Thesis-Open Access


Nutrients, when ingested in isolation from other food stuffs or in excess, may produce drug-like action on neurotransmitter activity in the CNS. Administration of aspartame exclusively or in combination with d-amphetamine was found to produce weight loss and display of emotionality in rats as measured in an open field apparatus. The possible neurochemical action of aspartame was discussed relative to the well documented stimulatory effects on catecholamines of d-amphetamine and three putative mechanisms were explored: 1) formation of minor amines from the increased precursor pool, 2) increased synthesis of catecholamines in response to the increased precursor pool, and 3) decrease in CNS levels of the putative neuro-inhibitor serotonin due to competative uptake at the blood-brain barrier.

Included in

Psychology Commons