Date of Award
Master of Science
Dr. Christine Byrd-Jacobs
Dr. John Spitsbergen
Dr. Jeremy Duncan
astrogliosis, astrocytes, zebrafish, peripheral, damage
Masters Thesis-Open Access
Traumatic brain injuries (TBIs), particularly if repetitive, cause massive disruptions of brain homeostasis, significant loss of neurons, and may result in death. Astrocytes are a type of cell that maintain brain homeostasis and neuronal health. Astrogliosis is a continuum of morphological and functional changes of astrocytes in response to damage. This can be neuroprotective or neurotoxic depending on the severity and type of injury. Global astrocyte scarring is typical of neurotoxic astrogliosis and is the source of secondary injury after TBIs. The adult zebrafish olfactory system is known for its capacity to recover from trauma, however, astrocytes in this system remain unexplored. Furthermore, it is unknown if astrogliosis will occur after repetitive damage to the periphery. This study examines this, and my hypothesis is that astrogliosis will occur. Indeed, it was shown that this does occur, but this process attenuated as the damage continued, and no scarring was evident. This is in contrast to what would be expected of mammalian astrocytes, which would have remained in their astrogliosis morphology and cause scarring. Since astrocytes are crucial mediators for recovery from trauma, further study of these cells in zebrafish may lead to novel medical treatments.
Scheib, Jackson, "Astrogliosis in the Adult Zebrafish Olfactory Bulb during Repetitive Peripheral Damage" (2019). Masters Theses. 4592.