Author

Goodwin

Date of Award

6-1999

Degree Name

Master of Arts

Department

Psychology

First Advisor

Dr. Lisa Baker

Second Advisor

Dr. Alan Poling

Third Advisor

Dr. Scott Kollins

Access Setting

Masters Thesis-Open Access

Abstract

(±)-3,4-Methylenedioxymethamphetamine (MDMA) produces effects in humans that are reportedly similar to those of CNS stimulants. However, drug discrimination studies in nonhumans have yielded inconsistent results regarding the similarities between MDMA and d-amphetamine. Sixteen male Sprague-Dawley rats were trained to discriminate d-amphetamine, MDMA, and saline in a three-lever drug discrimination procedure. In addition, differential outcomes were employed during drug discrimination training with eight of the rats but this did not appear to facilitate the acquisition of the discrimination. Cocaine (0.25-10.0 mg/kg) produced dose dependent increases in d-amphetamine-appropriate responding with complete substitution at the highest dose administered. LSD (0.02-0.16 mg/kg), produced dose dependent increases in MDMA-appropriate responding and nearly complete substitution (78%) at the 0.08 mg/kg dose. Fenfluramine (1.0-4.0 mg/kg), (+)MDA (0.375-1.5 mg/kg), and (-)MDA (0.375 mg/kg), all produced dose-dependent increases in MDMA-appropriate responding. The serotonin antagonist Pirenperone (0.16-0.64 mg/kg) partially blocked the stimulus cue of MDMA.

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Psychology Commons

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