Date of Award
Master of Arts
Dr. Lisa Baker
Dr. Ron Van Houten
Dr. Al Poling
α-pyrrolidinovalerophenone, 3, 4-methylenedioxypyrovalerone, drug discrimination, synthetic cathinone, sex differences
Masters Thesis-Open Access
Recreational use of synthetic cathinones, 3,4-methylenedioxypyrovalerone (MDPV) and α‐pyrrolidinovalerophenone (α‐PVP), has become increasingly popular, thus prompting characterization of their behavioral and neurochemical effects. MDPV has been studied for several years now, though there is still much unknown about α‐PVP, and its isomers. The primary objective of this study was to characterize the discriminative effects of α‐PVP and its isomers in comparison to MDPV. Male and female Sprague-Dawley rats were trained to discriminate 0.5mg/kg MDPV from saline injections under a fixed ratio 20 (FR 20) schedule of food reinforcement. Substitution tests were conducted with MDPV (0.05-0.5mg/kg), α‐PVP (0.05-0.5mg/kg), (S)-α‐PVP (0.05-1mg/kg) and (R)-α‐PVP (0.05-10mg/kg). All substances produced a dose-dependent increase in MDPV-lever responses and dose response curves were similar between males and females. Full substitution was observed in females at the highest dose of all test compounds and all except (R)-α‐PVP in males. These results illustrate that α‐PVP, and its isomers produce similar discriminative effects to those of MDPV with few differences between males and females. Although the current findings add to the established psychopharmacology of α‐PVP further investigations into its precise mechanisms of action are critical to advancing medical treatments for substance abuse disorders involving this and related synthetic cathinones.
Cargile, Kaley, "Evaluation of α-Pyrrolidindovalerophenone (α-PVP) and its Isomers in Male and Female Sprague-Dawley Rats Trained to Discriminate MDPV" (2021). Masters Theses. 5213.