Date of Award
Master of Science
Dr. Elke Schoffers
Dr. Sherine Obare
Dr. Ramakrishna Guda
1, 10-phenathroline, pKa, ionization constant, analvtical chemistry, titration
Masters Thesis-Abstract Only
Restricted to Campus until
1,10-Phenanthroline is a well-known and often-used ligand with a variety of interesting properties and applications to both organic and inorganic chemistry. Interest in novel 1,10-phenanthrolines substituted at the 5- and 6- position has grown recently due to their interesting fluorometric and spectroscopic properties. They have been evaluated recently for applications including chemical sensors, chemical indicators, pharmacological targets and bioactive reagents.
1,10-Phenanthroline, an epoxidated synthetic intermediate, and a novel 5,6- disubstituted aminoalcohol derivative were studied to determine the degree of influence that iterative physical and chemical transformations have on the donor properties of the N-C-C-N pocket. Multiple analytical techniques including potentiometry and spectrophotometry were optimized and applied to measure the change in the ionization constant as a result of the physicochemical changes.
Millheim, Dominic, "Physicochemical Characterization of Novel 1,1 0-Phenanthrolines" (2014). Masters Theses. 547.