Date of Award


Degree Name

Master of Science



First Advisor

Dr. Elke Schoffers

Second Advisor

Dr. Sherine Obare

Third Advisor

Dr. Ramakrishna Guda


1, 10-phenathroline, pKa, ionization constant, analvtical chemistry, titration

Access Setting

Masters Thesis-Abstract Only

Restricted to Campus until



1,10-Phenanthroline is a well-known and often-used ligand with a variety of interesting properties and applications to both organic and inorganic chemistry. Interest in novel 1,10-phenanthrolines substituted at the 5- and 6- position has grown recently due to their interesting fluorometric and spectroscopic properties. They have been evaluated recently for applications including chemical sensors, chemical indicators, pharmacological targets and bioactive reagents.

1,10-Phenanthroline, an epoxidated synthetic intermediate, and a novel 5,6- disubstituted aminoalcohol derivative were studied to determine the degree of influence that iterative physical and chemical transformations have on the donor properties of the N-C-C-N pocket. Multiple analytical techniques including potentiometry and spectrophotometry were optimized and applied to measure the change in the ionization constant as a result of the physicochemical changes.