Date of Award


Degree Name

Master of Arts



First Advisor

Dr. Alan D. Poling

Second Advisor

Dr. Jack Michael

Third Advisor

Dr. Lisa Baker

Access Setting

Masters Thesis-Open Access


Methamphetamine, a widely used recreational drug, is not known to produce physiological dependence. Few studies to date have examined whether behavioral dependence occurs upon sudden withdrawal from methamphetamine. In this study, pigeons (n=4) were trained to respond under a multiple FR 25 IRT > 6-s schedule of reinforcement, allowing for examination of drug effects upon a relatively high rate of responding (FR) and a relatively low rate of responding (IRT > t). Acute adminstrations of methamphetamine showed rate-dependent effects at low doses, while higher doses decreased responding under both schedules. Tolerance was demonstrated for all subjects except one at the highest dose level. Abrupt cessation of chronically administered methamphetamine did not disrupt responding maintained by either schedule. No evidence of behavioral dependence was demonstrated.