Mark LeSage

Date of Award


Degree Name

Master of Arts



First Advisor

Dr. Alan D. Poling

Second Advisor

Dr. Jack Michael

Third Advisor

Dr. William Redmon

Access Setting

Masters Thesis-Open Access


The physiological effects of (+) 3,4-methylenedioxymethamphetamine (MDMA) have been studied extensively. The behavioral effects of MDMA, however, have not been examined in detail. In an attempt to gain further information about its behavioral effects, the acute and chronic effects of MDMA were examined in pigeons responding under a delayed-matching-to-sample procedure with 0-, 3-, and 6-s delays. In the absence of drug, accuracy (percentage o f correct responses) was inversely related to delay length. When administered pre-chronically, MDMA (0.32 to 5.6 mg/kg) decreased accuracy and response rates at higher doses. Tolerance developed following chronic exposure to 3.2 mg/kg. Performance did not deteriorate when the chronic regimen ended, indicating an absence of behavioral dependence on the drug.

Included in

Psychology Commons