Date of Award
8-1984
Degree Name
Doctor of Philosophy
Department
Psychology
First Advisor
Dr. Alan D. Poling
Second Advisor
Dr. Frederick Gault
Third Advisor
Dr. David Lyon
Fourth Advisor
Dr. Clarence Goodnight
Abstract
The effects of tripelennamine (3, 6, 12, 18, and 24 mg/kg) and pentazocine (5, 10, 20, 30, and 40 mg/kg), given alone and in selected combinations, were determined in rats performing under fixed-ratio 30 and interresponse-time-greater-than-15-second schedules of food delivery. When given alone, tripelennamine and pentazocine produced statistically significant decreases in responding under the fixed-ratio 30 schedule, but did not significantly affect responding under the interresponse-time-greater-than-15-second schedule. Each drug alone significantly decreased the number of reinforcers (food pellets) earned relative to control values under both schedules. The effects of the two drugs in combination were supra-additive. That is, the effects of a given dose of tripelennamine and pentazocine together were identical in direction to, and significantly greater, than the arithmetic summation of the effects of the drugs given alone.
Access Setting
Dissertation-Open Access
Recommended Citation
Grossett, Deborah Lou, "Effects of Tripelennamine and Pentazocine Alone and in Combination on Schedule-Controlled Performance" (1984). Dissertations. 2370.
https://scholarworks.wmich.edu/dissertations/2370